Multicellular organisms, including humans, are composed of various organs, tissues, and cell types. Although all cells share the same genome, what causes this diversity? Moreover, why do cells arranged in three-dimensional configurations exhibit unique functions based on their spatial locations?

The solution to this mystery lies in spatiotemporal gene expression. The Oki Lab has developed a technique called PIC to comprehensively elucidate genes expressed locally. In addition, ChIP-Atlas, a data-mining suite for exploring epigenomic landscapes, has been developed to unveil the regulatory mechanisms of gene expression. By integrating these two approaches in our research, we are aiming to elucidate the etiology of diseases and advance applications in drug discovery.