Research Summary

Humans and other multicellular organisms are composed of a variety of organs, tissues, and cell types. Given that all cells share the same genome, why does such diversity arise? Why do cells arranged in three dimensions exhibit different functions depending on their location?

The key to solving this mystery lies in spatiotemporal gene expression. To address this, we developed PIC, a technology to profile transcriptomes in locally defined regions, and ChIP-Atlas, an integrative epigenome database for analyzing transcriptional regulation. By combining these approaches, we aim to elucidate disease onset mechanisms and drug actions.